Ramona Trebbien

Forskningsområder

Influenzavirus evolution i forhold til; patogenicitet, antiviral resistens, værtsfaktorer, receptorbinding, effekten på antigenicitet blandt andet i relation til vaccineeffektivitet mv. 

Antistofrespons mod influenzavirus efter vaccination og infektion i blandt andet særlige patientgrupper. 

Mekanismer bag zoonotisk transmission af influenzavirus mellem forskellige værter. 

Evolution og sygdomsbyrde af respiratorisk syncytial virus (RSV).

Ansvarsområder

Ansvarlig for det Nationale Influenza Center for WHO/Det nationale referencelaboratorium for influenza, med varetagelse af den nationale virologiske overvågning af influenzavirus samt respiratorisk syncytial virus (RSV). Det nationale referencelaboratorium for aviær influenzavirus samt newcastle disease virus (NDV) ligger i afsnittet, derudover arbejdes der med svineinfluenzavirus, porcine reproductive and respiratory syndrome virus (PRRSV), infektiøs laryngotracheitis virus (ILT), hvalpesygevirus (CDV), Aleutian mink disease virus (ADV), og Rabbit hemorragic disease virus (RDHV).

Partner fra Statens Serum Institut i FluZooMark projektet, der omhandler zoonotisk influenza. 

Publikationer

• Rose A, Kissling E, Emborg HD, Larrauri A, McMenamin J, Pozo F, Trebbien R, Mazagatos C, Whitaker H, Valenciano M; European IVE group. Interim 2019/20 influenza vaccine effectiveness: six European studies, September 2019 to January 2020. Euro Surveill. 2020 Mar;25(10):2000153. doi: 10.2807/1560-7917.ES.2020.25.10.2000153.

• Kvisgaard LK, Kristensen CS, Ryt-Hansen P, Pedersen K, Stadejek T, Trebbien R, Andresen LO, Larsen LE. A recombination between two Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-1) vaccine strains has caused severe outbreaks in Danish pigs. Transbound Emerg Dis. 2020 Mar 27. doi: 10.1111/tbed.13555. Online ahead of print.

• Trebbien R, Koch A, Nielsen L, Kur DK, Westerström P, Krause TG. A case of reassortant seasonal influenza A(H1N2) virus, Denmark, April 2019. Euro Surveill. 2019 Jul;24(27):1900406. doi: 10.2807/1560-7917.ES.2019.24.27.1900406.

• Trebbien R, Christiansen CB, Fischer TK. Antiviral resistance due to deletion in the neuraminidase gene and defective interfering-like viral polymerase basic 2 RNA of influenza A virus subtype H3N2. J Clin Virol. 2018 Feb 11;102:1-6. doi: 10.1016/j.jcv.2018.02.005. [Epub ahead of print]

• Jepsen*, MT, Trebbien*, R., Emborg, HD, Krause, TG, Schønning, K, Voldstedlund, M, Nielsen, J, Fischer, TK. Incidence and seasonality of respiratory syncytial virus hospitalizations in young children in Denmark, 2010 to 2015. Accepted for publication in Eurosurveillance 2017.*Shared first authorship.